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We value innovative research that leads to better treatments and health outcomes for children.

Marshfield Clinic Research Institute conducts research on pediatric diseases and treatment to improve children’s health and well-being.

The Research Institute has nationally-recognized centers in cancer research, epidemiology and population health, precision medicine and genetics, oral and systemic health, and agricultural safety and health. Our investigators participate in clinical trials in several pediatric subspecialty areas.

Our research centers are engaged in a wide variety of pediatric research topics, including the following:


We are a part of the Children’s Oncology Group at the National Cancer Institute. We offer the latest cancer treatments and clinical trials with investigational therapies. We also participate in research to improve cancer screening and prevention.  

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Vaccines have saved millions of children from serious illness. Measles, mumps, and the flu are just a few of the many childhood diseases that are prevented by vaccines. We conduct clinical trials for investigational vaccines that are not yet licensed, and we also study licensed vaccines that are routinely given to children. We are part of two national networks run by the Centers for Disease Control and Prevention. One network monitors the safety of all vaccines, and the other monitors the effectiveness of the flu vaccine each winter.

Clinical trials

In addition to vaccine trials, we participate in clinical trials of new antibiotics for serious pediatric infections. Pediatric specialists are also investigating new therapies for hypertension, kidney disease, epilepsy, migraines and rare genetic obesity syndromes.

Rare and genetic disorders

We are engaged in research exploring rare genetic syndromes including Smith-Magenis syndrome, Alström syndrome and Bardet-Biedl syndrome. By actively participating in precision medicine research, we hope to use genetic information to improve diagnosis, treatment and quality of life. 

Rural disease and injury prevention

We are leaders in disease and injury prevention in rural and agricultural environments. We are home to the federally-funded National Children’s Center for Rural and Agricultural Health and Safety. We are also pioneering research into the impact of the farm environment on young immune systems and mental health.

Oral health

We research links between dental and oral health to the entire body. This includes using data to better inform the public about oral health and participating in dental clinical research.